Isochores and tissue-specificity
نویسندگان
چکیده
منابع مشابه
STUDIES ON THE TISSUE SPECIFICITY OF COLONY STIMULATING FACTOR
In this study granulocyte-macrophage colony stimulating factor (CSF) was prepared from rabbit and guinea pig lung tissues. The biological activity of these CSFs was measured on semisolid agar culture and compared with those of mouse and rat. Weight of animals, incubation time and cross-reactivity of CSFs with different bone marrow sources were also investigated. The results showed that both...
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The statistical identification of the isochore structure, the variation in large scale GC composition, of mammalian genomes is a necessary requirement for understanding both the evolution of base composition and the many genomic features such as mutation and recombination rates which covary with base composition. We have developed a Bayesian method for isochore analysis, which we demonstrate to...
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The most deviant isochore pattern within mammals was found in rat and mouse; most other mammals possess a different kind of isochore organization called the "general pattern." However, isochore patterns remain largely unknown in rodents other than mouse and rat. To investigate the taxonomic distribution of isochore patterns in rodents, we sequenced the nuclear gene LCAT (lecithin:cholesterol ac...
متن کاملIndications of Tissue Specificity
That certain aspects of susceptibility to transplantable tumors are genetic phenomena has been demonstrated in the case of a carcinoma and a sarcoma of the Japanese Waltzing micel 2 and in two mammary adenocarcinomata occurring in a special strain of highly inbred common domestic mice. 4,5 The acceptance of the view that susceptibility to transplanted neoplasms is fundamentally a genetic proble...
متن کاملStudies in Tissue Specificity
Rat tumors and other tissues of foreign species grow actively in the chick embryo until the onset of a refractory period. Grafts of rat sarcoma established and growing actively at the onset of this period show a rapid cessation of growth between the 18th and 19th days of incubation. This is followed by a widespread degeneration of the rat cells and a marked activity of the connective tissue ele...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2003
ISSN: 1362-4962
DOI: 10.1093/nar/gkg699